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Spring 2020
The knee menisci are a pair of weight-bearing fibrocartilaginous tissues between the femoral condyles and tibial plateau. They are essential for mechanical load distribution and transmission, lubrication, and stability of the knee joint. Meniscus injury is a risk factor for the onset of knee...
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Differentiation of Primary Human Pro-Fibrotic Mesenchymal Cells Influenced by Extracellular Matrix Environment Determined by MicroRNA Expression
DownloadFall 2018
Fibrosis, a multi-faceted process that exacerbates numerous cardiovascular pathologies leading to heart failure, is the result of excessive extracellular matrix protein deposition. Although fibrosis is classically thought to be the result of myofibroblasts activated from interstitial...
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Investigating the Effect of Exogenously Supplemented FGF-18 on Expanded Meniscus Fibrochondrocytes Using a Cell Aggregate Model
DownloadSpring 2019
Osteoarthritis (OA) is a disease affecting >10% of Canadians and is associated with a huge economic burden on the Canadian economy and healthcare system. The disease is characterized by a variety of symptoms including chronic pain, inflammation, and decreased joint mobility. Therefore, the...
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Fall 2019
Matrix metalloproteinase-2 (MMP-2) is a zinc-dependent protease that proteolyzes numerous substrates both inside and outside the cell when activated during oxidative stress. However, the full gamut of MMP-2 substrates in myocardial oxidative stress injury is largely unknown. This thesis...