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Molecular and cellular analysis of skeletal muscle and neuronal development in a necdin-null mouse model of Prader-Willi syndrome
DownloadFall 2010
Prader-Willi syndrome (PWS) is a recurrent microdeletion syndrome characterized by severe obesity, hyperphagia, hypotonia, and developmental delay, and is caused by the loss of expression of four protein-coding genes and set of small nucleolar RNAs on chromosome 15. NDN, encoding the protein...
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Fall 2023
Adult hippocampal neurogenesis (AHN) involves generating hippocampal granule neurons and the subsequent integration of granule neurons into the hippocampus synaptic circuit. This continuous neuron generation supports ongoing learning and memory formation. Consequently, dysregulation of AHN and...