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A Search for the Physical Basis of the Genetic Code and Modeling Cancer Cell Response to Chemotherapy Using the Ising Model
DownloadFall 2020
Genetic code and its origin are one the most challenging problems in biochemistry and cell biology. Studying the genetic code evolution and the logic behind it is an interesting but a very complicated problem. The logic of the genetic code from an energetic and probabilistic perspective, the...
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Enhancement of menadione cytotoxicity by bicarbonate: redox cycling and a possible role for the carbonate radical in quinone cytotoxicity
DownloadSpring 2013
We investigated the effect of bicarbonate on quinone redox cycling and cytotoxicity. A cell-free system utilized menadione and ascorbic acid to catalyze a redox cycle, and we utilized murine hepatoma (Hepa 1c1c7) cells for in vitro experiments. Experiments were performed using low (2 mM) vs...
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Fall 2017
Drinking water disinfection effectively kills pathogens and prevents waterborne diseases, but it also generates a large number of water disinfection byproducts (DBPs). Epidemiological studies have consistently linked long-term consumption of chlorinated water with an increased risk of developing...