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Fall 2018
Sex traditionally has been an understudied variable in the chronic pain literature. However, more recent research has begun to explore the role of sex in the etiology of chronic pain. The present thesis adds to the current literature by expanding on research demonstrating the significant effect...
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Fall 2019
Persistent hyperexcitability in the primary sensory afferents contributes substantially to the onset and the maintenance of neuropathic pain. Inteleukin-1β (IL-1β) has been implicated to directly interact with interleukin 1 receptor type I (IL-1RI) expressed in dorsal root ganglion (DRG) neurons...
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Fall 2023
The immune system interacts reciprocally with the nervous system in order to accomplish facets of innate immunity via various mechanisms including toll-like receptors (TLRs). TLR activity leads to the release of cytokines which can effect acute and chronic pain states by promoting afferent neuron...