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Fall 2017
Kazemi Bajestani, Seyyed Mohammad Reza
Background: Cancer cachexia is referred to as a wasting condition, with skeletal muscle and fat loss. Although heart atrophy is recognized as a notable component of experimental cancer cachexia models, it has not been characterized in human studies. The contribution of cardiac structural and...
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Cardioprotective effects of n-3 and n-6 PUFA derived epoxylipids against age-related cardiac alterations
DownloadSpring 2021
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. A steady decline in mitochondrial function is recognized as an important biological consequence found in...
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Developmental Programming of Cardiac and Coronary Artery Dysfunction in Adult Male and Female Offspring Exposed to Prenatal Hypoxia
DownloadSpring 2023
Cardiovascular disease is a leading cause of global mortality and a major contributor to morbidity worldwide. Early epidemiological studies demonstrated that pregnancy complications can impact the health of the offspring in adult life. Fetal hypoxia is one of the most common complications of...
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Fall 2015
Youssef, Nermeen Hosny Ibrahim
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. . Studies on KATP deficient mice show that parameters of cardiac mechanical function are similar to those of wild-type mice under basal...