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Designing Nanomedicines for Breast Cancer Therapy: New Synthetic lipopolymers and Optimization of siRNA Formulations against Therapeutic Targets
DownloadFall 2024
In 2020, breast cancer became the most commonly diagnosed cancer worldwide. Conventional therapies like radiotherapy, chemotherapy and surgery have significant limitations and side effects that are mainly due to their inability to specifically target cancerous cells. Alternatively, gene therapy...
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Targeting Breast Cancer: Synthesis and Biological Evaluation of Novel D-Fructose Based Molecular Imaging Agents And Cytotoxic Noscapine Analogues
DownloadFall 2017
Among the characteristic hallmarks of cancer cells is their high replicative potential, which in turn leads to the overexpression of the facilitative hexose transporters (GLUTs) to provide the energy required for cell growth and proliferation. Interestingly, in 1996 the major D-fructose...
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Fall 2019
Breast cancer (BCa) is the most frequently diagnosed cancer in women worldwide. Treatment strategies often target hormone receptors on breast cancer cells. Triple-negative breast cancer (TNBC) is a BCa subtype where estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth...
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Spring 2020
Human cytomegalovirus (HCMV) infects 40–70% of the adult population in developed countries, and this rate increases with age. HCMV infection is normally latent with no noticeable symptoms in individuals with a healthy immune system. However, the infection can cause problems in immune-compromised...
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The role of the dietary long chain polyunsaturated fatty acid, docosahexaenoic acid, in prevention of breast cancer and its’ efficacy during neoadjuvant breast cancer chemotherapy
DownloadSpring 2021
Newell, Heather Marlene Marnie
Breast cancer (BC) is the most frequently diagnosed and the second leading cause of cancer related death in Canadian women. Docosahexaenoic acid (DHA) is an n-3 long chain polyunsaturated fatty acid (LCPUFA) that has shown efficacy in reducing BC cell growth, however its’ role in prevention of BC...
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Tracer Development for the Molecular Imaging of Breast Cancer: Synthesis and Biological Evaluation of C-3 Modified 2,5-Anhydro-D-mannitol Derivatives as Potential Tracer Molecules
DownloadSpring 2016
Mammography is the most frequently used imaging method for the detection of breast cancer. Despite the key role of mammography in the breast cancer detection, false-negative diagnosis by mammograms ranges from 4 to 34%. Positron emission tomography (PET), a tracer based molecular imaging method...