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Enhancement of menadione cytotoxicity by bicarbonate: redox cycling and a possible role for the carbonate radical in quinone cytotoxicity
DownloadSpring 2013
We investigated the effect of bicarbonate on quinone redox cycling and cytotoxicity. A cell-free system utilized menadione and ascorbic acid to catalyze a redox cycle, and we utilized murine hepatoma (Hepa 1c1c7) cells for in vitro experiments. Experiments were performed using low (2 mM) vs...
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Spring 2017
There is a close relationship between inflammation and cancer. At site of inflammation, reactive oxygen species (ROS) are generated, including hydrogen peroxide (H2O2). The generation of ROS could, in turn, activate transcription factors that are involved in inflammation, cellular transformation,...