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Fall 2023
Phosphoinositides (PIs) are membrane lipids that function as signaling molecules. PIs undergo phosphorylation and dephosphorylation at various positions to produce the seven known PI molecules. PIKfyve is a phosphoinositide kinase that produces phosphoinositide-3,5- bisphosphate (PI(3,5)P2) and...
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The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular Fissure
DownloadFall 2014
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
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Using a Zebrafish Animal Model to Identify the First Candidate Gene for Pigmentary Glaucoma
DownloadSpring 2019
Premelanosome protein (PMEL) was identified as a candidate gene for the development of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in humans. Mutations in PMEL were shown to cause pigment and ocular defects in several animals but there is currently no known PMEL associated...