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A role for the nuclear pore complex protein Nup170p in defining chromatin structure and regulating gene expression
DownloadSpring 2012
The spatial organization of chromosomal loci within the nucleus can have a significant influence on transcriptional activity. Transcriptionally active genes are generally positioned within the nuclear interior. By contrast, the positioning of genes at the nuclear periphery is often correlated...
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How studying the interaction of Sir4 with a subset of Nups uncovered a new chromatin bound complex.
DownloadFall 2017
The nucleus is the defining feature of eukaryotic cells and its major function is to house the cell’s genome and segregate it from the surrounding cytoplasm. The membranes encapsulating the nucleus constitute the nuclear envelope (NE). The interactions between the NE and chromatin facilitate the...