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- 8X-ray crystallography
- 13D structure
- 1Acidithiobacillus ferrooxidans
- 1Anti-PrP antibody
- 1Antibody fragments
- 1Lazareno-Saez, Christelle
- 1Leung, Charles
- 1Mizianty, Marcin J
- 1Ritchie, Dustin B.
- 1Swayampakula, Mridula
- 1Wong, Joyce JW
Characterization, Structure and Mechanism of Sulfide:quinone oxidoreductase (SQR) from Acidithiobacillus ferrooxidansDownload
A key enzyme in maintaining sulfide homeostasis is the membrane-associated flavoenzyme sulfide:quinone oxidoreductase (SQR) found in nearly all domains of life (except plants). SQR maintains a critical equilibrium between sulfide (H2S, HS- and S2-) and elemental sulfur (S0), coupling the...
Computational support systems for prediction and characterization of protein crystallization outcomesDownload
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
The study of heterobimetallic complexes (having two different metal atoms) involves combining the unique properties of each metal, which can give rise to interesting contrasts in reactivity compared to either metal alone. With two different metals incorporated into one complex, a more diverse...
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
More than 90% of human genes undergo a processing step called splicing, whereby non-coding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Roughly 50% of human genetic diseases correspond to aberrant splicing. Splicing is...
Rhomboids are a family of intramembrane serine peptidases that cleaves a peptide bond of a substrate protein in the lipid bilayer. Various cellular processes such as cell differentiation and apoptosis have been linked to rhomboids proteolytic activty. More precisely, active and inactive rhomboids...
Bacterial conjugation is the process of plasmid DNA transfer from a donor cell to a recipient cell. This process is mediated in F-like plasmids by proteins expressed by the tra operon. The relaxosome forms at oriT (origin of transfer), where the nicking and unwinding of a single-stranded copy of...
Transmissible Spongiform Encephalopathies (TSEs) are a class of fatal, infectious neurodegenerative disorders affecting the central nervous system. The critical event in the pathogenesis of TSEs is the autocatalytic conformational conversion of the cellular prion protein (PrPC) into an...