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Fall 2013

Miyata, Sarah, T

Vibrio cholerae is the Gram-negative bacterium responsible for the diarrheal disease cholera. In addition to the well-characterized virulence factors – cholera toxin and the toxin co-regulated pilus – used by this organism to cause watery diarrhea, V. cholerae uses the type VI secretion system...

Spring 2015

Acosta Amador, Paula N

The gram negative bacterial cell envelope is composed of the outer membrane, the periplasm and the inner membrane. These compartments are exposed directly to changes in the environment that are sensed and adapted to through different signaling transduction pathways. This often occurs through...

Fall 2021

Davoodi, Saeideh

Immune and metabolic pathways collectively contribute to the containment of microbial invaders, and persistent activation of immune responses contribute to the development of severe metabolic disorders. To determine how interaction between innate immune system and metabolic responses affected...

Spring 2019

Benjamin Kostiuk

Vibrio cholerae is a diverse bacterial species that causes a wide range of disease,ranging from the diarrheal disease cholera by toxigenic strains to mild gastroenteritiscaused by non-toxigenic strains. Toxigenic strains are able to cause more severe diseasedue to the secretion of cholera toxin....

Spring 2024

Xu, Xinyue

To maintain an effective barrier, intestinal epithelial progenitor cells must divide at a rate that matches the loss of dead and dying cells. Epithelial damage during most enteric infection accelerates cell proliferation and tissue repair via multiple stress responses. However, infection with the...

Fall 2020

Hussain, Nora A.S.

The type VI secretion system (T6SS) is a contact-dependent molecular weapon used by bacteria to transport a variety of effectors into neighbours. Attacked cells must have immunity proteins specific to each incoming effector in order to neutralize their cytotoxic effects. Vibrio cholerae, a...

Fall 2017

Kirchberger, Paul C.

Vibrio cholerae, because of its role as the causative agent of cholera pandemics, is an extraordinarily well studied microorganism. Decades of research have uncovered a plethora of molecular mechanisms and a wealth of genomic information related to the organisms’ lifestyle as a pathogen. V....

Spring 2022

Islam, Mohammad Tarequl

Phylogenomic structuring of the Vibrio cholerae clade is an important area of study in the context of the alarming spike of human morbidities due to environmental pathogens around the world. Even after decades of research, the structuring of natural populations of V. cholerae and its sister...

Fall 2019

Nasreen, Tania

Cholera, a severe life-threatening waterborne diarrheal disease, has been endemic to the Ganges delta for centuries. Vibrio cholerae, the causative agent of this disease, is a natural inhabitant of brackish water. Amongst the 200 serogroups identified so far, only O1 and O139 were found...

Fall 2015

Unterweger, Daniel

Vibrio cholerae is a Gram-negative bacterial species that consists of over 200 serogroups with differing pathogenic potential. Only O1 serogroup strains have been associated with the pandemic spread of cholera, a disease characterized by watery diarrhoea that can lead to severe dehydration and...