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Skip to Search Results- 1Burton, Robyn-Lee
- 1Chahal, Manik
- 1Fagan-Garcia, Katharine
- 1Fung, Rachel D
- 1Heydari, Maysam
- 1Khairy, Mostafa
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
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Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopy
DownloadSpring 2020
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
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Investigating Radiation in Combination with Oncolytic Vaccinia Virus to Improve the Treatment of Glioblastoma
DownloadFall 2023
Glioblastoma (GBM) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GBM treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GBM cells....
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
DownloadFall 2012
Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Fall 2022
Glioblastoma has a devastating prognosis, and a remarkably low survival rate. Current therapeutic strategies including surgery, radiation and temozolomide are only useful as a palliative therapy, with no significant increase in overall survival. In this study, we investigated multiple therapeutic...
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Fall 2019
Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...
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Fall 2009
This thesis addresses the challenge of prognosis, in terms of survival prediction, for patients with Glioblastoma Multiforme brain tumors. Glioblastoma is the most malignant brain tumor, which has a median survival time of no more than a year. Accurate assessment of prognostic factors is critical...
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The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...