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- 1Briney, Bryan
- 1Burton, Dennis R.
- 1Cottrell, Christoph A.
- 1Hsueh, Jessica
- 1Johnson, Janelle L
- 1Kulp, Daniel W.
Characterization of the Humoral Immune Response Elicited Against a Prophylactic Vaccine Composed of Recombinant Envelope Glycoproteins from Hepatitis C VirusDownload
A global prophylactic vaccine for Hepatitis C Virus (HCV) remains elusive. The diversity of the virus is a major hurdle; a successful vaccine will need to protect against all 7 HCV genotypes (gt). Our lab is developing a vaccine comprising the two envelope glycoproteins of HCV (E1E2). An...
Dendritic cells (DCs) play a central role in shaping antigen-specific immune response. Antibody-mediated antigen targeting to DC-specific surface receptors is a promising approach to enhance vaccine efficacy. The objective of this thesis was to develop DC-targeted nanoparticulate formulations for...
Objectives: This thesis consists of 3 partial vaccine economic evaluations. The objectives were to: 1) estimate the effectiveness of Canada’s universal varicella childhood immunization strategy on varicella-related hospitalizations, 2) measure the economic impact of Alberta’s universal childhood...
Exploring the Association between Parental Concern about Vaccine Safety and Incomplete Childhood Immunization: A Multivariate ModelDownload
High levels of immunization coverage are required to maintain control of infectious diseases that previously caused significant illness and death in Canada. However, childhood immunizations have been so successful that many Canadians have never seen the impact of these diseases, with some parents...
Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodiesDownload
Hsueh, Jessica, Menis, Sergey, Sanders, Rogier W., Ozorowski, Gabriel, Pauthner, Matthias, Voss, James E., van Gils, Marit J., Torres, Jonathan L., McCoy, Laura E., Ward, Andrew B., Wilson, Ian A., Schief, William R., Macauley, Matthew S., Burton, Dennis R., Cottrell, Christoph A., Messmer, Terrence, Sok, Devin, Briney, Bryan, Kulp, Daniel W.
A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to...
Investigation of the Molecular Mechanisms That Determine Isolate-Specific, Antibody-Mediated Neutralization of HCV infectivityDownload
It is estimated that there are about 1.75 million new Hepatitis C Virus (HCV) infections per year worldwide and around 20% will develop liver cirrhosis or liver cancer if left untreated. Direct acting antiviral drugs are available for the treatment of HCV with success rates of over 90%. But...