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Characterization of the Herpes Simplex Virus 1 VP11/12-tyrosine based binding motifs for Src family kinases, p85, Grb2 and Shc
DownloadSpring 2018
Infection with HSV-1 triggers several events specifically designed to manipulate cell signal transduction pathways. Two major signaling cascades targeted by the virus are the PI3K/Akt-pathway and the TCR-signaling pathway. Prior to the studies presented in this thesis, it was known that the...
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Herpes Simplex Virus Requires VP11/12 to Activate Src Family Kinase-PI3 Kinase-Akt Signalling
DownloadFall 2010
This thesis defines a novel role for the Herpes Simplex Virus (HSV) tegument protein, virion protein (VP) 11/12 as a modulator of host cell signalling. Studies aimed at examining infection induced lymphocyte inactivation, revealed that VP11/12 is tyrosine phosphorylated in three lymphocyte...
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Spring 2013
AKT inhibits apoptosis and stimulates cap-dependent translation by phosphorylating key downstream cellular proteins. Many viruses therefore activate the PI3-kinase-AKT signaling pathway to promote cell survival and viral protein synthesis. HSV-1 activates AKT during lytic infection and the...
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Fall 2013
Herpes simplex virus type 1 is a ubiquitous human virus that causes cold sores and, increasingly, genital herpes. Upon virion-cell fusion, tegument proteins diffuse into host cytosol and, as such, are poised to remodel signalling pathways. Tegument proteins of interest here are virion protein...