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Skip to Search Results- 2Leng, Roger (Laboratory Medicine and Pathology)
- 1Bamforth, Fiona (Laboratory Medicine and Pathology)
- 1Barry, Michele (Medical Microbiology and Immunology)
- 1Glover, Mark (Biochemistry)
- 1Leng, Roger (Department of Laboratory Medicine and Pathology)
- 1Persad, Sujata (Department of Pediatrics)
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Fall 2015
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
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Spring 2023
The human cell is equipped with highly intricate molecular signaling mechanisms to orchestrate the cellular responses to various stresses that endanger cellular genome integrity. Thus, genome integrity is always kept under surveillance to prevent and protect the cell from passing damaged DNA that...
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Fall 2016
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...
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Fall 2010
The significance of poxvirus manipulation of the host ubiquitin proteasome system has become increasingly apparent. Ubiquitin is post-translationally added to target proteins by a highly conserved enzymatic cascade, typically resulting in protein degradation via the 26S proteasome. The highly...
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Spring 2015
Cancer and tumor suppressors have been highly associated with many cancer researches. The main function of these proteins is to detect any error in DNA that might eventually leads to abnormal cell division and repair these errors; hence eliminating the risk of cancer development. Many researches...