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Fall 2024
DNA serves as a detailed blueprint for cellular functions, but continuous exposure to damaging agents poses a threat to genomic stability, especially through DNA double-strand breaks. Cells utilize two main repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR), to...
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Fall 2017
The information contained in our genome is essential for the proper functioning of different physiological processes in cells that are required for our growth and survival, making the maintenance of genome integrity a task of utmost priority. Our cells have evolved a highly elaborate, complex and...
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Spring 2013
K63-linked polyubiquitin is synthesized by the E2 Ubc13, and plays non-degradative roles in immunity and the DNA damage response, yet a full molecular understanding of its synthesis and subsequent recognition remains incomplete. Although previously considered a slow enzyme, we demonstrate that...