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Investigation of the role of UBE4B ubiquitin ligase in p53 regulation in response to DNA damage in ATM-proficient and ATM-deficient cells
DownloadFall 2017
The tumour suppressor protein p53 maintains genomic integrity by coordinating the DNA damage response, which includes growth arrest, DNA damage repair, and apoptotic cell death. p53 is mutated in more than 50% of human cancer, which reflects its importance. The complex mechanism that controls the...
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Spring 2023
The human cell is equipped with highly intricate molecular signaling mechanisms to orchestrate the cellular responses to various stresses that endanger cellular genome integrity. Thus, genome integrity is always kept under surveillance to prevent and protect the cell from passing damaged DNA that...