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Fall 2017
The pathological events initiating diabetic cardiac changes in response to chronic hyperglycemia and hyperinsulinemia remain unclear. Due to the high metabolic activity of the heart, and its sensitivity to acute changes in oxygen and substrate flux, mitochondrial dysfunction has been proposed as...
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Effects of dietary and pharmacological interventions on pancreatic β-cell compensation in Nile rats: a model for spontaneous type 2 diabetes
DownloadFall 2019
Insulin-secreting pancreatic β-cells adapt to obesity-related insulin resistance via increases in insulin secretion and β-cell mass, which is referred to as β-cell compensation. Failed β-cell compensation predicts the onset of type 2 diabetes (T2D). However, the mechanisms underlying β-cell...