SearchSkip to Search Results
- 7Tumor necrosis factor
- 2Cytokines--Physiological effect
- 1Awad, Ahmed
- 1King, Sharla J.
- 1Lapchak, Peter H.
- 1Peake, Kyle
- 1Wride, Michael Anthony.
- 1Yui, Sui-Jane.
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
Tumor necrosis factor triggers the expression and activation of matrix metalloproteinases through NADPH-dependent superoxide productionDownload
Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis investigates TNF in triggering the expression and activation of matrix metalloproteinases (MMPs) in pressure overload cardiac disease, and explores the role of superoxide. Cardiac pressure overload was...