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Fall 2011
RNA polymerase III (RNAPIII) pre-initiation complexes at tRNA genes naturally cause replication fork pausing in the yeast Saccharomyces cerevisiae, and interference with replication is known to have deleterious effects on genome stability. It follows that repression of tRNA gene transcription...
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Fall 2017
Herpes simplex virus 1 (HSV-1) is a nuclear-replicating, double-stranded (ds) DNA virus. HSV-1 genes are expressed in a coordinate manner. The tegument protein VP16 first activates expression of the five immediate-early (IE) genes. Two IE proteins, ICP4 and ICP0, then activate early (E) and...