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- 4Total synthesis
- 1Allylboration reaction
- 1Combinatorial chemistry
This thesis describes the studies towards the total synthesis of MPC1001F, a triketomonothiopiperazine natural product. In section 2.1, the first route, based on previous studies, reached the pyrrolidinone/diketopiperazine system with correct stereochemistry but did not go to completion due to...
This thesis describes advanced model studies directed to the synthesis of CP- 225,917 and CP-263,114, complex natural products that have been shown to inhibit enzymes that are involved in cholesterol biosynthesis and in the development of many cancers. A route was devised to the functionalized...
The thesis describes synthetic studies towards MPC1001F, a triketopiperazine-dihydrooxepin natural product. Another related member of this class of natural products is MPC1001 with an epidithiodioxopiperazine core and potent antitumor activity. Our goal was to construct the molecular skeleton of...
α-exo-Alkylidene γ-lactones and γ-lactams via 2-alkoxycarbonyl allylboronates: mechanistic studies, diversity-oriented synthesis and target-oriented synthesisDownload
Allylboration reactions have been thoroughly utilized in organic chemistry since it was discovered that they could add in a nucleophilic fashion to aldehydes and ketones in 1964. Modification of allylboronates and the substrates that they can react with has been the focus of many research groups...