This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Alteration of astrocyte markers and phosphorylation of tau protein in kainic acid-treated animal model of Temporal Lobe Epilepsy
DownloadFall 2022
Kainic acid, an analogue of the excitatory neurotransmitter glutamate, when administered systemically can trigger seizures and neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (mTLE), which affects ~50million people globally. Evidence suggests that...
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Fall 2021
Chronological aging is one of the greatest risk factors of tauopathies, yet our understanding about the underlying molecular mechanism is limited. Studying physiological aging often requires an extended timeline and thus presents a significant hurdle for modeling late-onset disorders. In this...
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Tau seeding in a HEK cell model is influenced by aggregation inducers and cellular chaperones
DownloadFall 2022
The tau protein is a microtubule associated protein whose misfolding and subsequent aggregation have been associated with a group of neurodegenerative diseases known as tauopathies. Studying tau in a lab setting has been crucial for the advancement of knowledge and technology used to treat people...