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Function and Regulation of TRPP2 and TRPP3, and identification of pore gates of TRP channels
DownloadSpring 2017
The transient receptor potential (TRP) superfamily of cation channels is composed of eight subfamilies, TRPC/V/M/P/ML/A/N/Y, and play distinct sensory roles in response to various environmental stimuli. TRPP2, or polycystin-2, is mutated in autosomal dominant polycystic kidney disease (ADPKD)....
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Fall 2012
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a prevalent genetic disorder where multiple fluid-filled cysts destroy kidney architecture, eventually requiring hemodialysis or kidney transplant. Approximately 15% of cases of ADPKD cases are caused by defects in TRPP2, a calcium...