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Investigating and characterizing the direct binding interactions between chemotherapeutic cisplatin and pattern recognition receptor, Toll-like Receptor 4
DownloadFall 2022
Cisplatin is one of the most effective chemotherapeutic agents available. Unfortunately, adverse drug reactions - cisplatin-induced toxicities - often limit the use of cisplatin. These toxicities develop in at least half of those treated, are diverse, and are especially problematic for pediatric...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...