This is a decommissioned version of ERA which is running to enable completion of migration processes. All new collections and items and all edits to existing items should go to our new ERA instance at https://ualberta.scholaris.ca - Please contact us at erahelp@ualberta.ca for assistance!
Search
Skip to Search Results- 1Al-Jaaidi, Abdullah G.
- 1Dutra, Bruna
- 1Dutta,Indrani
- 1Garside, Erin
- 1Grewal, Charnpal
- 1Malhotra, Darpan
-
Spring 2023
The discontinuous split-gene structure is a core feature of eukaryotic gene architecture and requires pre-mRNA splicing to remove silent intron sequences from the initial pre-mRNA transcript before it becomes a mature mRNA suitable for protein synthesis. Splicing begins with recognition of both...
-
Spring 2022
Eukaryotes feature a split gene structure in which pre-mRNAs are spliced into mature RNAs prior to the translation of proteins. The splicing process is catalyzed by a dynamic multi-subunit molecular machine known as the spliceosome that assembles in a stepwise fashion. An early complex formed in...
-
Modelling Repair Techniques for Reinforced Concrete Bridge Barriers using Glass Fibre Reinforced Polymer Bars
DownloadSpring 2021
In an era where bridge deterioration due to corrosion has become evident and a pressing concern for future reinforced concrete bridge construction, glass fibre reinforced polymer (GFRP) reinforcement has emerged as a feasible alternative to steel due to its superior corrosion resistance. Research...
-
Fall 2021
Primary Biliary Cholangitis (PBC) is a complex cholestatic liver disorder with both environmental and genetic factors that contribute to disease. While the etiology remains poorly understood, our lab continues to characterize the role of a human betaretrovirus (HBRV) in the disease process. Based...
-
Spring 2014
The Reelin signaling pathway is involved in the migration of neurons during brain development. Reelin binding to the receptors VLDLR (Very Low Density Lipoprotein Receptor) and ApoER2 (Apolipoprotein E Receptor 2) leads to Dab1 phosphorylation, thereby activating a cascade of downstream...
-
SLC4A11 in Blinding Endothelial Corneal Dystrophies: Characterization, Molecular Defect and Potential Therapeutic Strategy
DownloadFall 2019
Endothelial Corneal Dystrophies (ECD), genetic blinding diseases with a heterogeneous pathophysiology, are the leading cause of endothelial keratopathy (corneal transplants). Patients manifest symptoms, including corneal edema with increased corneal thickness and loss of corneal endothelial cells...
-
Fall 2015
Over 90% of eukaryotic genes are initially expressed as precursor-messenger RNAs (pre-mRNAs) that contain coding exon sequences interrupted by non-coding intron sequences. The introns are excised and exons are ligated together to form messenger RNA (mRNA) through a process called splicing....
-
Spring 2019
Exons, protein coding regions in eukaryotic genes, are interrupted by non-coding introns that must be removed from transcribed pre-mRNA prior to translation into protein. Introns are removed, and exons ligated, in a process called pre-mRNA splicing. Conserved sites within the intron, the 5′ and...
-
Spring 2012
More than 90% of human genes undergo a processing step called splicing, whereby noncoding introns are removed from initial transcripts and coding exons are ligated together to yield mature messenger RNA. Splicing involves two sequential transesterification reactions catalyzed by a large...