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- 2Breast cancer
- 2Cancer stem cells
- 1DDX17
- 1Estrogen receptor positive (ER+)
- 1Intra-tumour heterogeneity
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DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cells
DownloadSpring 2016
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...
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Delineation of Molecular Mechanisms Underlying the Pathobiology of ALK-positive Anaplastic Large-cell Lymphoma
DownloadSpring 2017
ALK-positive anaplastic large-cell lymphoma (ALK+ALCL) is a rare type non-Hodgkin lymphoma of null/T cell original, preferentially occurs in children and young adults. Approximately 85% of ALK+ALCL patients carry the gene translocation t(2;5)(p23;q35), which results in the generation of the...
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MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF DISTINCT BREAST CANCER CELL SUBPOPULATIONS PURIFIED USING A SOX2 REGULATORY REGION 2 TRANSCRIPTION ACTIVITY REPORTER
DownloadFall 2015
Sex-determining Region Y-box 2 (Sox2) is a transcription factor integral to the maintenance of pluripotency in embryonic stem cells. In recent years, Sox2 expression has been detected and implicated in the pathogenesis of breast and other cancers. Clinically, Sox2 expression has been associated...
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Fall 2019
Within a tumour, only a subset of cells are able to initiate neoplasms when transplanted or following localization to different organs. These tumour-initiating cells, often called cancer stem cells (CSCs) due to their high cellular plasticity, were found to exhibit particular resistance to...