SearchSkip to Search Results
- 1Blair, Salvatore D
- 1Clifford, Alexander M
- 1Dibrov, Pavel
- 1Dymowska, Agnieszka K
- 1Fliegel, Larry
- 1Guffey, Samuel C
Branchial Ionoregulatory Mechanisms of Sodium Regulation in Freshwater Salmonids with Conservational Implications for Arctic Grayling (Thymallus arcticus)Download
This thesis on fish osmoregulation focuses particularly on the mechanisms utilized by freshwater salmonids to absorb Na+ ions from dilute hypotonic environments and at the same time, their capacity to make necessary changes in order to tolerate higher saline environments. In this thesis, I...
The molecular identity of the Na+ uptake mechanism across the gills of freshwater fish has been the subject of lively debate for decades. Despite the extensive evidence for NHE mediated Na+ uptake, thermodynamic constraints on the function of NHEs at low ion concentrations and low environmental...
Osteoarthritis is characterized by pain and inflammation in joints, typically weight-bearing joints such as the knee. An early warning sign of osteoarthritis is the loss of proteoglycan molecules in the cartilage matrix. A surrogate method for measuring proteoglycan loss is detection of sodium...
Respiration, Acid/Base, Ammonia and Ionoregulatory Strategies in the Pacific hagfish (Eptatretus stoutii)Download
Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...
25 years after the first sodium images of the human brain were created, sodium MRI remains on the periphery of MR research, despite intimate sodium involvement in cellular metabolism and implicated abnormal concentrations in numerous disorders. The difficulties of sodium MRI include not only...
I have examined solute transport in two fishes at the whole-animal, tissue, and molecular levels. In the Pacific hagfish, I measured the kinetics of phosphate absorption in isolated gut, skin, and gill preparations, and implicated an NaPi-II transporter based on RT-PCR results and the kinetics of...