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Fall 2022
The compartmentalization of subcellular functions facilitates the regulation of biochemical reactions and cellular processes. The compartmentalization of the eukaryotic genome into the nucleus by the nuclear envelope (NE), for example, facilitates various DNA metabolic activities. The NE is...
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Spring 2019
In yeast, subtelomeric chromatin is silenced and positioned at the inner nuclear membrane (INM) through the interaction of proteins that comprise the heterotrimeric SIR complex with INM proteins. Telomeres reside primarily at the INM using partially redundant tethering mechanisms mediated by the...