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Exploring the Interplay between Donor Sex, CD71+ RBCs, Erythrophagocytosis and Hospital-onset Sepsis
DownloadSpring 2024
Transfusion of red cell concentrates (RCCs) is common for treating anemia in Intensive care unit (ICU) patients, but it may result in adverse outcomes like sepsis, potentially due to donor sex-related immune responses. CD71+ RBCs, which are immature, may influence erythrophagocytosis, where the...
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Mechanisms of Neonatal Intestinal Failure-Associated Liver Disease: Exploring the Gut-Liver Axis
DownloadSpring 2018
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...