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Cryo-electron microscopy of SERCA interacting with oligomeric phospholamban and oligomeric sarcolipin
DownloadFall 2011
In 2007, heart disease was the second leading cause of death in Canadians. In heart muscle cells, calcium (Ca2+) is released from the sarcoplasmic reticulum (SR) during contraction and must be replenished for relaxation to occur. Three proteins restore Ca2+ to the SR following contraction: the...
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Spring 2020
Calcium homeostasis is essential and central to a variety of cellular processes from cell life and death pathways to metabolism to muscle contraction. One component that is essential to intracellular calcium regulation is known as the sarco(endo)plasmic reticulum Ca-ATPase, or SERCA. SERCA...
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Fall 2013
In human cells, oscillations in calcium concentration serve as a mechanism for controlling a variety of physiological processes including muscle contraction and relaxation. The sarcoplasmic reticulum (SR) is a calcium storage organelle in muscle cells that contains a calcium pump (SERCA) required...
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Spring 2020
Oscillating cytosolic calcium concentrations dictate the contraction-relaxation cycles of muscle cells. Calcium release from the sarcoplasmic reticulum (SR) to the cytosol stimulates muscle contraction, while active transport of calcium back into the SR triggers muscle relaxation. Calcium...