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Cryo-electron microscopy of SERCA interacting with oligomeric phospholamban and oligomeric sarcolipinDownload
In 2007, heart disease was the second leading cause of death in Canadians. In heart muscle cells, calcium (Ca2+) is released from the sarcoplasmic reticulum (SR) during contraction and must be replenished for relaxation to occur. Three proteins restore Ca2+ to the SR following contraction: the...
In human cells, oscillations in calcium concentration serve as a mechanism for controlling a variety of physiological processes including muscle contraction and relaxation. The sarcoplasmic reticulum (SR) is a calcium storage organelle in muscle cells that contains a calcium pump (SERCA) required...