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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...
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Unmasking the in vivo importance of STAT3 in multiple myeloma using three-dimensional culture and nanoparticle drug delivery system
DownloadSpring 2019
Multiple myeloma (MM) is a hematological malignancy which is caused by aberrant accumulation of monoclonal plasma cells (PCs) within the bone marrow. The oncogenesis of MM is mediated by chromosomal aberrations as well as the tumor microenvironment in the bone marrow. Signal transducer and...