This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
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Spring 2022
Positive strand RNA ((+)ssRNA) viruses are some of the most important pathogens that impact the public health, economy, and quality of life. The interferon (IFN) response plays a critical role in innate immune response targeting (+)ssRNA viruses, which in turn have evolved various strategies to...
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Development and Application of Methods for Sensitive and Specific Detection of SARS-CoV-2 and Variants in Clinical and Environmental Samples
DownloadFall 2024
The COVID-19 pandemic, caused by SARS-CoV-2, had far-reaching global health consequences, with the virus spreading rapidly via respiratory droplets and aerosols. Accurate and timely diagnostic testing became critical for guiding public health policies and preventing the spread of infections. The...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Fall 2022
Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important emerging human pathogens that have disrupted global health. More therapeutic and prophylactic treatments for the diseases caused by the emerging viruses are needed. Expansion of our knowledge on the...
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Experimental Evaluation and Modeling of an In-duct Ultraviolet Germicidal Irradiation (UVGI) System for Bioaerosol Disinfection
DownloadSpring 2024
Airborne pathogen transmissions have played critical roles in the previous COVID-19 pandemic and various respiratory epidemics, such as influenza, severe acute respiratory syndrome (SARS), etc. Inhaling airborne pathogens can cause adverse health effects, resulting in respiratory infections,...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
DownloadFall 2023
Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...
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Fall 2024
The COVID-19 pandemic accelerated the development of mRNA vaccines, yet iden- tifying the optimal mRNA sequence for human use, particularly for the SARS-CoV- 2 spike protein, remains challenging. This thesis focuses on optimizing the open reading frame (ORF), a crucial mRNA component composed of...
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Spring 2023
The nucleus is a hallmark organelle of eukaryotes. It separates the genetic material from the rest of the cytoplasm using a selectively permeable double phospholipid bilayer called the nuclear envelope (NE). The NE contains numerous pores with embedded macromolecular structures called nuclear...
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Small-molecule inhibitors of non-structural protein 15 (NSP15) for the treatment of SARS-CoV-2
DownloadFall 2022
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. As of 2022, the viral spread is still ongoing and has claimed the lives of at least 6.24 million globally. Despite being more than two years into the...
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Fall 2021
The ongoing COVID-19 pandemic is impacting the lives of billions of people worldwide as well as the medical and socioeconomic systems. The genomic variability of this virus makes it capable of being prevalent in humans around the world for a long time and migrating from one place to another. It...