Search
Skip to Search Results-
Fall 2015
Folding of biomolecules is an important problem in structural biology. The physical folding can be projected as a diffusive search over an energy landscape whose dimensions scale by all the internal degrees of freedom which a biomolecule possesses. To explore this idea, folding is studied from...
-
High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamer
DownloadSpring 2010
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
-
Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...