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- 2Retinal development
- 1Alternative splicing
- 1Disabled-1
- 1Phosphorylation
- 1Protein analysis
- 1Rainbow-trout
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Spring 2011
The Reelin-Disabled-1 (Dab1) signaling pathway plays a key role in regulating neuronal positioning and synaptic plasticity. Binding of Reelin to its receptors induces tyrosine phosphorylation of the intracellular adaptor protein Dab1. Tyrosine-phosphorylated Dab1 not only rapidly transmits the...
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Proteomic analysis of opsins and thyroid hormone-induced retinal development using isotope-coded affinity tags (ICAT) and mass spectrometry
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Veldhoen, Kathy M., Allison, W. Ted, Hawryshyn, Craig W.
Purpose: Analyses that reveal the relative abundance of proteins are informative in elucidating mechanisms of retinal development and disease progression. However, popular high-throughput proteomic methods do not reliably detect opsin protein abundance, which serve as markers of photoreceptor...
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