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Skip to Search Results- 1Allison, W. T.
- 1Andres, Alexis D
- 1Casey, Geoffrey A
- 1Cheng, Caroline ST
- 1Crichton,Paul
- 1Erickson, Timothy
- 2Waskiewicz, Andrew (Biological Sciences)
- 1Allison, W. Ted (Biological Sciences, Medical Genetics)
- 1Andrew Waskiewicz, Biological Sciences
- 1Dr. Andrew Waskiewicz (Department of Biological Sciences, University of Alberta)
- 1Eisenstat, David (Oncology/Medical Genetics)
- 1Harvey, Stephen (Physiology)
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Spring 2016
Normal eye development requires a complex series of morphological movements and ocular patterning with aberrant eye development resulting in birth defects and retinal dystrophies. Eleven percent of paediatric blindness is caused by microphthalmia (small eyes), anophthalmia (no eyes) and coloboma...
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Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the Retina
DownloadFall 2022
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
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Electrophysiological Properties of a Quail Neuroretina Cell Line (QNR/D): Effects of Growth Hormone?
DownloadFall 2012
The expression of retinal ganglion cell protein markers and voltage-gated ion channels in QNR/D cells was investigated using immunocytochemistry and the whole cell patch clamp technique, respectively. Additionally, since these cells express growth hormone and growth hormone receptor, the effects...
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Fall 2017
Development of the vertebrate ocular structures requires the cooperative interactions of transcription factors, signalling proteins, external growth factors, and epigenetic regulatory factors. Consequently, misregulation of these cues can result in a number of developmental and functional...
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Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
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Fall 2014
The growth and development of an organ is a multi-step process. It involves initial specification of the progenitor cells to become a particular cell type, proliferation of those cells for organ growth, and organization of the cells into a final functional tissue. The growth and development of...
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Fall 2012
Sensory systems are complex structures that receive stimuli from the surrounding environment and convert them into interpretable information. In the visual system, light hitting the eye is transmitted to the brain in a way that preserves the spatial conformation of the pictures we see. Retinal...
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Patterning the zebrafish visual system requires the actions of Pbx transcription factors, and a downstream growth factor, Gdf6a
DownloadFall 2010
The zebrafish visual system relies on positional information in the retina and optic tectum, so that the spatial fidelity of light signals that enter the eye are preserved for visual processing. This positional information is essential for ordered topographic mapping of retinal ganglion cell...
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Fall 2017
Photoreceptors (the light-sensitive cellular mediators of vision in the eye) are divided into two classes: rods, which are sensitive to dim light and responsible for vision in low-light conditions, and cones, which are sensitive to specific wavelengths of light, and are responsible for daytime...