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Spring 2010
Anion Exchanger 1, AE1, is a membrane glycoprotein that functions as a dimer in the red blood cells (RBC) as well the kidney. It functions to exchange Cl- for HCO3- in an electroneutral manner, with the RBC AE1 having an additional function in maintaining its biconcave shape. Mutations in AE1...
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Fall 2015
Congenital Hereditary Endothelial Dystrophy, Harboyan Syndrome and Fuchs’ Endothelial Corneal Dystrophy are three forms of heterogeneous, genetic corneal blindness. Mutations in the membrane protein SLC4A11 have been found to cause cases of these diseases. Most mutations in SLC4A11 cause the...
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Spring 2012
This dissertation targets the topic of rescue of Jews in the Holocaust in World War II. It offers a thorough examination of the defiance mechanics of rescue and looks at how precisely rescuers undermine the pillars of totalitarian regimes. The locus for the empirical part is the Slovak State, a...
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Fall 2012
The kidney anion exchanger 1 (kAE1) is crucial in the regulation of physiological pH by facilitating Cl-/HCO3- exchange. Inability to do so results in distal renal tubular acidosis (dRTA), which is more often due to mutations leading to mis-localization of kAE1, rather than complete abolishment...