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- 3Vaccinia virus
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Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopy
DownloadSpring 2020
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
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Fall 2014
Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured vaccine used exclusively in China. To take advantage of the next generation sequencing...
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Vaccinia virus DNA polymerase and ribonucleotide reductase: their role in replication, recombination and drug resistance
DownloadSpring 2010
Despite the eradication of smallpox, poxviruses continue to cause human disease around the world. At the core of poxvirus replication is the efficient and accurate synthesis and repair of the viral genome. The viral DNA polymerase is critical for these processes. Acyclic nucleoside phosphonate...
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Fall 2021
Poxviruses encode many genes that are orthologs of cellular genes. These orthologs serve many functions, but those that are of most interest are ones that have evolved further and now serve an immune-evasion function. Such genes were likely first acquired by poxviruses through some form of...