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Subject: Reactive oxygen species Departments: Department of Surgery Collections: Graduate and Postdoctoral Studies (GPS), Faculty of

  • The Use of Doxycycline in Asphyxiated Newborns

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    Fall 2013

    LaBossiere, Joseph R

    Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...

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