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- 9Reactive oxygen species
- 1ATP-sensitive potassium channel
- 1Antimicrobial peptides
Deciphering the mechanism of cytotoxicity and cancer-selective activity of the delocalized lipophilic cation D112Download
Chemotherapeutic drugs that are used in anti-cancer treatments often cause death of both cancerous and noncancerous cells. This non-selective toxicity is the root cause of untoward side effects that limits the effectiveness of therapy. To improve the therapeutic options for cancer patients, there...
The current practice of red blood cell banking for transfusion medicine relies primarily on a six-week liquid storage. A growing demand for red blood cell (RBC) products has prompted the search for alternative preservation methods including dry storage. Being desiccation sensitive, attempts to...
The cardiac sodium-calcium exchanger (NCX) is an important membrane protein which regulates cellular calcium necessary for the optimal contractile function of the heart. NCX has become a focal point in ischemic heart disease (IHD) research as evidence suggests that reactive oxygen species (ROS)...
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic [Ca2+] ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...
The endosymbiont Wolbachia pipientis induces the expression of host antioxidant proteins in an Aedes albopictus cell lineDownload
Wolbachia are obligate intracellular bacteria which commonly infect arthropods. They are maternally inherited and capable of altering host development, sex determination, and reproduction. Reproductive manipulations include feminization, male-killing, parthenogenesis, and cytoplasmic...
Complex II, or succinate dehydrogenase, is a vital component of aerobic life. Its function is critical for both the tricarboxylic acid cycle and the mitochondrial respiratory chain since it catalyzes the oxidation of succinate to fumarate, liberating two electrons that feed into the lipid-soluble...
Tumor necrosis factor triggers the expression and activation of matrix metalloproteinases through NADPH-dependent superoxide productionDownload
Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis investigates TNF in triggering the expression and activation of matrix metalloproteinases (MMPs) in pressure overload cardiac disease, and explores the role of superoxide. Cardiac pressure overload was...
Unique cellular interactions between the obligate intracellular bacteria Wolbachia pipientis and its insect hostDownload
Wolbachia are maternally inherited obligate intracellular bacteria found in arthropods, where they induce feminization, male-killing, parthenogenesis, and cytoplasmic incompatibility (CI). CI is conditional male sterility, in which Wolbachia-infected males successfully mate with infected females,...