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Development of novel compounds for the molecular imaging of hypoxia: 18F-labeled nitroimidazoles and hypoxia inducible factor 1 alpha (HIF-1a)-targeting compounds
DownloadSpring 2023
Imaging of hypoxia has been previously achieved using positron emission tomography (PET) with radiotracers such as [18F]fluoroazomycin arabinoside ([18F]FAZA) [1] or [18F]fluoromisonidazole ([18F]FMISO) [2]. These typical nitroimidazole containing compounds are reductively trapped in hypoxic...
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Studies on C–F Activation and Radiofluorination Reactions: Interactions of Fluorine with Boron and Silicon Lewis Acids
DownloadFall 2022
Boron and silicon Lewis acids form strong bonds with fluorine. This ability facilitates a range of interesting reactivity. For example, small boron/silicon reagents are at the forefront of C-F activation, a field focused on cleaving one or more C-F bonds in organofluorine compounds. In addition...