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Investigation of mRNP export kinetics and gene expression regulation by the DEAD-box protein Dbp5p in Saccharomyces cerevisiae
DownloadFall 2019
The intricate architecture of the eukaryotic cell, which includes the partitioning of the cell into discrete membrane bound organelles, necessitates that various cargos must cross the nuclear envelope (NE). Nuclear pore complexes (NPCs) are large macromolecular assemblies embedded within the NE...
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Nuclear accumulation of polyadenylated noncoding RNA leads to a breakdown in nuclear RNA homeostasis
DownloadSpring 2020
The biogenesis and processing of messenger RNAs (mRNAs) is central to the gene expression program. In eukaryotic cells, mRNAs must also be exported from nucleus to cytoplasm as part of the gene expression pathway. In this work, mutations in 1047 essential genes of Saccharomyces cerevisiae (S....