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Fall 2015
Folding of biomolecules is an important problem in structural biology. The physical folding can be projected as a diffusive search over an energy landscape whose dimensions scale by all the internal degrees of freedom which a biomolecule possesses. To explore this idea, folding is studied from...
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Force spectroscopy of the frameshift signal from West Nile virus reveals multiple folding pathways and structural heterogeneity
DownloadSpring 2019
Programmed ribosomal frameshifting (PRF) represents an important mechanism for translational genetic recoding, especially in viruses. The components of a PRF stimulator have been well characterized, though accounting for the variation in the frameshift stimulating efficiency has thus far been...