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Skip to Search Results- 2Proteolysis
- 1 PrPC
- 1CRISPR/Cas9
- 1Calcium sensitizer
- 1Cardiac troponin complex
- 1Compound library screen
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Fall 2021
Neurodegenerative diseases caused by prions afflict both humans and animals, and result from conformational conversion of the cellular prion protein, PrPC, coded for by the PRNP gene, to an isoform called PrPSc. The infectious agent of PrPSc assembles into aggregate structures and can continue...
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Mutations, post-translational modifications, and small molecule binding to the cardiac troponin complex alter cardiac contractile function
DownloadFall 2021
Ischemic heart disease is the leading cause of death worldwide. It can lead to acute myocardial infarction, commonly known as a “heart attack”, in which heart muscle dies due to disruption of its oxygen and blood supply. Even if patients survive a heart attack and receive the best medical therapy...