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A novel human mutation in the SLC9A1 gene results in abolition of na+/H+ exchanger activity
Download2015-01-01
The SLC9A1 gene, the Na+/H+ exchanger isoform 1 is the principal plasma membrane Na+/H+ exchanger of mammalian cells and functions by exchanging one intracellular proton for one extracellular sodium. The human protein is 815 amino acids in length. Five hundred N-terminal amino acids make up the...
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Elucidation of molecular mechanisms of physiological variations between bovine subcutaneous and visceral fat depots under different nutritional regimes
Download2013
Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim
Adipose tissue plays a critical role in energy homeostasis and metabolism. There is sparse understanding of the molecular regulation at the protein level of bovine adipose tissues, especially within different fat depots under different nutritional regimes. The objective of this study was to...
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Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
Download2015-01-01
Mohamed, Iman A., Gadeau, Alain-Pierre, Fliegel, Larry, Lopaschuk, Gary, Mlih, Mohamed, Abdulrahman, Nabeel, Filmore, Natasha, Mraiche, Fatima
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin (OPN) expression in models of cardiac hypertrophy (CH), and the...
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Stop codon polymorphisms in the human SLC9A1 gene disrupt or compromise na+/H+ exchanger function
Download2016-01-01
Li, Xiuju J., Augustine, Aruna, Chen, Shuo, Fliegel, Larry
The NHE1 isoform of the mammalian Na+/H+ exchanger is a ubiquitous plasma membrane protein that regulates intracellular pH in mammalian cells by removing one intracellular proton in exchange for one extracellular sodium. Deletion of the NHE1 gene (SLC9A1) affects the growth and motor ability of...