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Spring 2023
Prion diseases are rare, inexorably progressive, and fatal neurodegenerative disorders, with no therapy other than palliation. The key event in the pathogenesis of prion diseases is the conformational conversion of the cell-surface glycoprotein (PrPC), from a predominantly α-helical structure...
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Fall 2019
Human prion diseases present as sporadic, familial, infectious, or iatrogenic forms. They include diseases such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and Fatal Familial Insomnia (FFI). The wide range of phenotypic variation in human prion diseases is...
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Fall 2020
Neurodegenerative diseases are a rising concern worldwide. Currently 10% of people aged 65 or more are diagnosed with a neurodegenerative disease and this number is predicted to triplicate by 2050. In developed societies approximately one percent of the global gross domestic product is allocated...
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Fall 2023
Prion diseases are a group of deadly neurological disorders caused by the abnormal folding of the prion protein into an infectious form known as PrPSc. Chronic wasting disease is a prion disease affecting cervids such as deer, elk, moose, and reindeer. Despite ongoing efforts to understand prion...
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Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...