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Mechanisms of Prion Disease: Initial Misfolding of the Prion Protein and Metabolomic Changes in the Brain
DownloadFall 2020
Prion diseases are neurodegenerative diseases that are caused by the misfolding and aggregation of cellular prion protein (PrPC) into the pathogenic form termed PrPSc. To contribute to a better understanding of the mechanism of prion disease, in this thesis I present my work on the structural...
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Fall 2021
Neurodegenerative diseases caused by prions afflict both humans and animals, and result from conformational conversion of the cellular prion protein, PrPC, coded for by the PRNP gene, to an isoform called PrPSc. The infectious agent of PrPSc assembles into aggregate structures and can continue...