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Studying Systemic Metabolic Remodeling and Abnormal Mitochondrial Signaling in Primary Biliary Cholangitis
DownloadFall 2024
Primary biliary cholangitis (PBC) is linked with the production of anti-mitochondrial antibodies (AMA) targeting pyruvate dehydrogenase complex-E2 subunit (PDC-E2). Cholangiocytes from PBC patients express increased PDC-E2, which is thought to result in loss of tolerance to mitochondrial...
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