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Skip to Search Results- 1Banadyga, Logan Elliott
- 1Burles, Kristin A
- 1Campbell, Stephanie D
- 1Desaulniers, Megan Amanda
- 1Harrison, Melissa L
- 1Irwin, Chad Robert
Results for "departments_tesim:"Department of Microbiology""
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Fall 2012
One of the most notable features of poxviruses is their ability to regulate cellular signaling pathways, including the ubiquitin-proteasome system. Ubiquitin plays a crucial role in the fate of a protein. Typically poly-ubiquitinated proteins are degraded by the 26S proteasome. The Skp1,...
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Fall 2015
Many cellular processes are regulated by the ubiquitin proteasome system (UPS), which utilizes the polypeptide ubiquitin to mark proteins for destruction via the 26S proteasome. Since the UPS plays an important role in cellular homeostasis, many viruses have evolved strategies to regulate the...
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Determination of Oligomeric State and Role of the Acidic C Terminal Tail of Vaccinia Virus I3 Single Stranded DNA Binding Protein
DownloadFall 2013
Single-stranded DNA (ssDNA) binding proteins (SSB) play a major role in DNA replication, recombination, and repair, by protecting ssDNA from nuclease attack and removing inhibitory secondary structure. Poxviruses are large double stranded DNA viruses that replicate within the cytoplasm of cells,...
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Ectromelia Virus Encodes A Novel Family Of Ankyrin/F-box Proteins That Manipulate The SCF Ubiquitin Ligase And NF-κB Activation
DownloadSpring 2012
Ectromelia virus (ECTV) is the causative agent of lethal mousepox, and is highly related to the human pathogen, variola virus, the causative agent of smallpox. Poxviruses contain large dsDNA genomes that encode numerous open reading frames that manipulate cellular signalling pathways. We used...
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Investigating the role of the base mismatches within the hairpin ends of vaccinia virus genome in viral life cycle
DownloadSpring 2023
The genome of poxviruses consists of a double-stranded DNA that is flanked by two AT-rich hairpin ends encoding mismatched nucleotides. These mismatched structures are composed of incompletely base paired regions forming extra-helical loops. Though the functionality of these mismatches has not...
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Spring 2012
Apoptosis, an evolutionarily conserved cell death programme, is a potent barrier against virus infection. Central to this process are mitochondria, which harbour cytochrome c and other apoptosis-inducing factors. Once released, these factors activate a caspase cascade that culminates in cell...
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Investigations into Differences between Vaccinia and Myxoma Virus Plaquing Properties Identifies Strategies for Increasing the Oncolytic Efficacy of Myxoma Virus
DownloadFall 2013
Despite both being poxviruses, vaccinia (VACV) and myxoma (MYXV) form very different plaque types. VACV plaques are large and show a central clearing of cells, while MYXV plaques are smaller and result in a clumping of cells. VACV spread is promoted by the formation of an enveloped form of virus...
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Spring 2016
Poxviruses, such as vaccinia virus (VACV) and myxoma virus (MYXV), actively modulate various cellular structures and functions to ensure effective replication and transmission. In the contrary, cells use several restriction mechanisms to mitigate these viruses. This evolutionary relationship is...
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Poxviral manipulation of Bcl-2 proteins: fowlpox virus FPV039 and deerpox virus DPV022 inhibit apoptosis by neutralising Bak and Bax, while Noxa contributes to vaccinia virus-induced apoptosis
DownloadSpring 2011
Poxviruses are renowned for encoding proteins that modulate virtually every aspect of the host immune system. One effective barrier against virus infection is apoptosis, a form of programmed cell death. Apoptosis is controlled at the mitochondria by pro- and anti-apoptotic members of the highly...
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Fall 2015
Natural Killer (NK) cells are a major part of the innate immune defence against viral infection and tumours. However, our understanding of how NK cells can be exploited for antiviral and antitumor therapy is still in its infancy. We are interested in the interplay between NK cells and Vaccinia...