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Skip to Search Results- 5Positron Emission Tomography
- 3Breast Cancer
- 2Cancer
- 1Adenovirus
- 1Amino Acid Membrane Transporters
- 1CA125
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Fall 2014
Rationale: Ovarian cancer is the most lethal malignancy of the female reproductive system. ~80% of ovarian cancers are epithelial in origin and commonly classified as Epithelial Ovarian Cancer (EOC). This malignancy is characterized by an overexpression of Cancer Antigen-125 (CA125) – a cell...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Evaluation of Hypoxia Induced Regulation of Nucleoside and Amino Acid Membrane Transporters in Breast Cancer
DownloadSpring 2020
Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...
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Synthesis and Characterization of Novel Radiolabelled Substrates for Imaging of GLUT5 Expression in Human Breast Cancer Using Positron Emission Tomography
DownloadFall 2012
Overactive glucose transport and metabolism has been widely recognized as one of the fundamental hallmarks of cancer and its progression. The facilitative glucose transporter GLUT1 is widely overexpressed in many tumor types compared to their untransformed counterparts. Due to this, the glucose...
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Target Volume Delineation in Dynamic Positron Emission Tomography Based on Time Activity Curve Differences
DownloadSpring 2013
Tumor volume delineation plays a critical role in radiation treatment planning and simulation, since inaccurately defined treatment volumes may lead to the overdosing of normal surrounding structures and potentially missing the cancerous tissue. However, the imaging modality almost exclusively...